LSD, Psilocybin, MDMA, Ayahuasca and Cannabis. For so long these powerful psychedelic substances have been seen as harmful or self-indulgent. But recent clinical trials by well-respected researchers have been treating a range of afflictions, including PTSD, addictions and psychological stresses suffered by late-stage terminal cancer patients. Could their use be a rational and valuable addition to therapeutic practice? Could they play a role in helping to alleviate human suffering? Strictly focusing on the science and medicinal properties, and through interviews with the world’s foremost researchers, writers, psychologists and pioneers in psychedelic psychotherapy, the film explores the history and medicinal potential of the famous five.